Where is the vitamin D receptor?

In humans, the vitamin D receptor is encoded by the VDR gene located on chromosome 12q13. 11. Like the iNKT cells, there are also fewer CD8αα/TCRαβ precursors in the thymus of VDR-KO animals. Moreover, to complete development CD8αα/TCRαβ cells must travel from the thymus to the gastrointestinal tract where IL-15 induces proliferation and upregulation of CD8αα. Due to decreased levels of IL-15 receptor expression VDR-KO CD8αα/TCRαβ cells proliferate poorly, resulting in a diminished mature CD8αα/TCRαβ population in the VDR-KO gut (Yu et al., 2008; Bruce and Cantorna, 2011; Ooi et al., 2012). These data illustrate that in contrast to conventional T cells, VDR expression is mandatory for development of both iNKT cells and CD8αα/TCRαβ T cells. VDR is expressed in most tissues of the body, and regulates transcription of about 900 genes involved in intestinal and renal transport of calcium and other minerals. In a study by Patel et al. (1995) plasma toxins from uremic patients was shown to bind to the patient’s VDR, thereby disrupting binding of VDR-RXR to DNA resulting in a diminished VDR response. It so appears that post-translational modifications of VDR adjust VDR activity in both health and disease. [Retrieved from https://www.frontiersin.org/articles/10.3389/fimmu.2013.00148/full]; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789451/],

Bones provide both skeletal scaffolding and space for hematopoiesis in its marrow. Previous work has shown that these functions were tightly regulated by the nervous system. The central and peripheral nervous systems tightly regulate compact bone remodeling, its metabolism, and hematopoietic homeostasis in the bone marrow (BM). Accumulating evidence indicates that the nervous system, which fine-tunes inflammatory responses and alterations in neural functions, may regulate autoimmune diseases. Neural signals also influence the progression of hematological malignancies such as acute and chronic myeloid leukemias. Here, we review the interplay of the nervous system with bone, BM, and immunity, and discuss future challenges to target hematological diseases through modulation of activity of the nervous system. [Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119651/]. The lymphatic system consists of lymphatic organs such as bone marrow, the tonsils, the thymus, the spleen, and lymph nodes. All lymphocytes develop in bone marrow from immature cells called stem cells. [Retrieved from https://www.medicalnewstoday.com/articles/285666].

Note: In humans, the vitamin D receptor is encoded by the VDR gene located on chromosome 12q13. 11. VDR is expressed in most tissues of the body, and regulates transcription of genes involved in intestinal and renal transport of calcium and other minerals (See asc, adhd, epilipsry and schzophrinia & Chromosome 12 above).

Similarly, early last year, researchers from institutes in Germany and Greece reported a mechanism in the brain’s outer cortical cells that produces a novel ‘graded’ signal all on its own, one that could provide individual neurons with another way to carry out their logical functions. By measuring the electrical activity in sections of tissue removed during surgery on epileptic patients and analyzing their structure using fluorescent microscopy, the neurologists found individual cells in the cortex used not just the usual sodium ions to ‘fire’, but calcium as well. [Retrieved from https://www.sciencealert.com/a-never-before-seen-type-of-signal-has-been-detected-in-the-human-brain?fbclid=IwAR3sZiK3xsrIVnHirG-RjcIKY9NW5czdUk3iPK8dURZnz-qXaKsXJwE6sDs].

Hyponatremia is not only the most common electrolyte disorder but is also associated with higher infection rate [1], cardiovascular disease [2, 3], and mortality risk [4, 5]. Central nervous system (CNS) symptoms are the main manifestations of hyponatremia [6]. Think about how dementia cause an electrolyte imbalance? Residents who have very advanced dementia may also develop electrolyte imbalance because their brain no longer reminds their body to drink or accept fluids when offered to them. How is an electrolyte imbalance diagnosed? Electrolyte imbalance is usually diagnosed by blood tests. Does level(s) affect dementia? Several studies reported that chronic hyponatremia resulted in mild cognition impairment (MCI) [7, 8], which in turn was associated with increased risk of progression to dementia [9] or death [10]. [Retrieved from https://www.ncbihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462431/].

Similarly, think about manganese and neurodegenerative diseases. Manganese [Mn] is an essential ubiquitous trace element required for normal growth, development and cellular homeostasis [1]. Specifically, Mn is important in bone formation, fat and carbohydrate metabolism, blood sugar regulation, and calcium absorption. In humans and animals, Mn functions as a required cofactor of several enzymes necessary for neuronal and glial cell function, as well as enzymes involved in neurotransmitter synthesis and metabolism [2, 3, 4] [Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230726/].

NOTE: What surprised researchers was that patients with depression were prone to IBD. Zhang speculates that this discovery may have to do with what is known as the gut-brain axis, a scientifically established connection between the gastrointestinal system and the central nervous system, which consists of the spinal cord and the brain. [Retrieved from https://neurosciencenews.com/ibd-depression-20724/].

Endogenous regeneration in the brain is the ability of cells to engage in the repair and regeneration process. … Another benefit that can be achieved by using endogenous regeneration could be avoiding an immune response from the host. There are therapeutic approaches for boosting thymus function. Likewise, the causes age-related thymic involution have been suggested along with several possible mechanisms identified including blockages of T-cell receptor gene rearrangement, decreased self-peptide MHC molecules, and depletion of T-cell progenitors [Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837659/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750859/;

979-020-0173-8].

Note: In the brain, hormones alter or change the production of gene products that participate in synaptic neurotransmission as well as affect the structure of brain cells. As a result, the circuitry of the brain and its capacity for neurotransmission. I give natural and holistic ways to improve your thymic hormone function and cell-mediated immunity… “Although epigenetic modulators that control effector status in Th17 cells have been identified 15, 21, the TF regulators that globally program the capacity of CD4+ T cells to dynamically control their functional identity in response to changing contexts are mostly undefined.” Retrieved from cell gene and https://www.pnas.org/content/115/8/1883 (see HPA & Pineal Body, Pituitary & Adrenal Glands below).

Supplementation with these nutrients has been shown to improve thymic hormone function and cell-mediated immunity such as…Zinc, vitamin B6, and vitamin C are perhaps the most critical. Zinc may be the critical mineral involved in thymus gland function and thymus hormone action. Hematite worn around the neck brings balance to both the etheric body and the physical body. Due to its magnetic nature and our ying-yang energies, it’s nature is to bring us back to equilibrium. Plus, Note: I go much deeper than supplements like neurometric education (read below) to avoid early thymic involution and/or dysfunction, imbalance, etc. …. (Retrieved from https://www.frontiersin.org/articles/10.3389/fimmu.2020.01745/full; https://www.frontiersin.org/research-topics/11340/new-insights-into-thymic-functions-during-stress-aging-and-in-disease-settings).

magnetic– rTMS is a depression treatment (as well dementia) typically used when other approaches—such as medications—haven’t been effective for a patient. It is estimated that approximately 40 percent of people with major depression do not respond to antidepressants. They found, that by stimulating the dorsolateral pre-frontal cortex, several other regions of the brain were also activated. These other regions are involved in multiple functions—from managing emotional responses to memory and motor control. Again, the participants then underwent another four weeks of rTMS treatment and the team assessed whether the activated regions were associated with patients having fewer symptoms of depression when their treatment ended. Retrieved from https://neurosciencenews.com/rtms-depression-20612/].

*ACE- (aka Anger Enzyme) Angiotensin-converting enzyme (EC 3.4.15.1), is a central component of the renin–angiotensin system (ras), which controls blood pressure by regulating the volume of fluids in the body (See Gut-brain axis and Neurotoxicity). Corticotropin-releasing hormone (see hypothalamus below)- Stress induces the hypothalamic production and release of CRH, which then causes the activation of the CRH receptor (CRHR) type 1 (CRHR-1) in the anterior pituitary (see HPA below) to stimulate ACTH release, as well as proopiomelanocortin (POMC) expression and processing. Rationale: The corticotropin-releasing hormone (CRH) stimulation test has been used as a diagnostic test in both adrenal insufficiency and Cushing syndrome. Glucocorticoids are essential steroid hormones secreted from the adrenal gland in response to stress. (Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1819560/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1819560/; https://www.frontiersin.org/research-topics/7323/involvement-of-neuro-immune-mechanism-and-brain-gut-axis-in-pathophysiology-of-mood-disorders#articles).

συνάγω (Strong’s #4863 — Verb — sunago — soon-ag’-o ) “to bring together” (sun, “together,” ago, “to bring”), is used in the sense of “bestowing,” or stowing, by the rich man who laid up his goods for himself, Luke 12:17,18 . See ASSEMBLE , COME , GATHER , LEAD , RESORT , TAKE

A growing body of evidence suggests that chronic anger can take a daily toll on your cardiovascular health and immune system. Letting go of the bitterness you feel toward another person can lower your anxiety, which directly impacts both your mental and physical health. Basically, feeling bad is bad for you—especially if those feelings are due to bitter or traumatic memories that frequently to mind unbidden. [Retrieved from https://getpocket.com/explore/item/forgiving-people-is-good-for-your-health-here-s-how-to-do-it?utm_source=pocket-newtab]. Note: If something confounds you, as well could make someone angry, it makes you feel surprised and confused, often because it does not meet your predefined expectations (perceptions).

*Aside: An estimated 6.2 million Americans age 65 and older are living with Alzheimer’s dementia in 2021. The number of people with dementia is expected to increase to 152 million by 2050. My dad being one of those. The fundamental principle of Montessori approach is to value a patients’ naturally inquisitive and improving symptoms of dementia to foster learning in an intuitive and natural way.

In Alzheimer’s disease, tau and another protein called amyloid-beta build up into tangles and plaques—known collectively as aggregates.

Interesting Research- Dementia, those with memory loss, they did have faster thinning of the entorhinal cortex due to amyloid level as well as brain shrinkage of the hippocampus. Relevantly, the Wnt pathway has been recognized as critical for the central nervous system development, several Wnt components retain their expression in the adult brain, including the hippocampus, and have proven to be fundamental in both the development and function of synapses (Inestrosa and Arenas, 2010; Inestrosa and Varela-Nallar, 2015). Altogether, these findings strongly suggest that Wnt signaling might be down-regulated during aging, leading to increased vulnerability of the neural network and increasing the risk for the onset and progression of age-related pathologies, such as AD. Wnt inhibitors, including the secreted-frizzled-related protein 1 and 2 (SFRP-1 and SFRP-2) and Dickkopf-1 (Dkk-1), all them antagonists at the cell surface. As a result, mice deficient in Dkk-1 exhibit enhanced spatial working memory and memory consolidation and also show improvements in affective behavior (Caricasole et al., 2003, 2004) [Retrieved from Scienmag. “SCIENMAG.” What Comes First, Beta-Amyloid Plaques or Thinking and Memory Problems?, apple.news/A0bfYT-YLR2u8kRquMsjKRA; Scienmag. “SCIENMAG.” What Comes First, Beta-Amyloid Plaques or Thinking and Memory Problems?, apple.news/A0bfYT-YLR2u8kRquMsjKRA?fbclid=IwAR2; https://www.alz.org/media/documents/alzheimers-facts-and-figures.pdf; https://www.frontiersin.org/articles/10.3389/fpsyt.2021.737270/full?fbclid=IwAR1M2cFp6D3BRbSd4rBFnJs-UxFBBG-CDWIoxP38tUYq5UNuY5mgQoQcsfQ].

A combination of patient-reported subjective cognitive impairment and measurable clinical symptoms, such as amyloid-beta accumulation in the cerebrospinal fluid, may help in the early diagnosis of Alzheimer’s disease. Subjective memory disorders in conjunction with conspicuous levels of beta-amyloid proteins in the cerebrospinal fluid are a strong indication of developing Alzheimer’s disease. This is the conclusion of a DZNE study involving about 1,000 older adults. [Retrieved from https://neurosciencenews.com/feeling-measure-alzheimers-20581/].

***Ask me about the dorsal raphe nucleus at the brainstem, TDP-43 (FTLD–TDP) folding proteins, beta-amyloid plaque build-up, Dkki-1 at the midbrain stem, prefrontal cortex and the frontal lobe for Alzheimer’s (dyslexia as well). Also ask me about the RAS-conscious around the age of three, ARAS and God awareness age 21–25 (Petty, Peter G. “Consciousness.” Journal of Clinical Neuroscience, vol. 3, no. 4, 1996, p. 390., doi:10.1016/s0967-5868(96)9004.

“Young children who are neglected or maltreated have abnormal patterns of cortisol production. Also, a family’s experience of economic hardship is associated with elevated cortisol levels among children. A mother’s depression during her child’s early years can lead to even higher cortisol levels. Under such conditions, the child becomes more vulnerable to a range of stress-related disorders affecting both mental health (e.g., depression, anxiety disorders, alcoholism, drug abuse) and physical health (e.g., cardiovascular disease, diabetes, stroke).” Also, in the early years, Comfort seeking may be difficult for people with intellectual or multiple disabilities, because they are often less securely attached or they lack the behaviors to seek comfort. In general, the experience of stress, coping with stress, attachment behaviors and disabilities seem to be closely related in this population (Janssen et al., 2002; Schuengel and Janssen, 2006; Schuengel et al., 2013; Giltaij et al., 2016). [Retrieved from https://neurosciencenews-com.cdn.ampproject.org/c/s/neurosciencenews.com/alzheimers-progression-19565/amp/?fbclid=IwAR1A1JkYfAouT5rwApfIN27RLWYlB3XO5T5go_pw6EDH4d8PCTgpN8gws3U; https://www.gse.harvard.edu/news/uk/08/05/stress-levels-and-developing-brain?fbclid=IwAR3dbxQa6noieCc9agDesnleGc3wg24YPc3gNHgi1gug5J06WHwNmRCHrsk#.YIbY-LbnnmY.twitter%20C; https://www.frontiersin.org/articles/10.3389/feduc.2020.540387/full].

Pineal Body, Pituitary & Adrenal Glands (see hypothalamus below)- synthesizes hormones such as our melatonin, serotonin, and dopamine and cortisol which helps you respond to stress (reading for example) and has many other important functions. Acetylcholine and dopamine are the bridge of the synaptic gap between neurones, are the ‘neurotransmitters in mind’ that form the substance of the volume, which is essential for consciousness. Also melatonin studies recently show that melatonin exhibits many bioactivities, such as antioxidant activity, anti-inflammatory characteristics, boosting immunity, anticancer activity, cardiovascular protection, anti-diabetic, anti-obese, neuroprotective and anti-aging activity.

Note: Students with (anger) Sympathetic Functional System Dominance (SFD) are deficient in dopamine, melatonin, and have hyer-norepinephrine production (diligence- fight, flight, flee & hyperarousal). Students with (shame) Parasympathetic Functional System Dominance (PFD) are deficient in serotonin, melatonin, and have hypo-norepinephrine production (hypoarousal, memory retrieval, diligence/motivation-freeze). Note: The pineal gland helps with a meditative state if the head is covered- it’s great for Calm (I will write more about calm ahead! Varied is, of course, Total Functional System Dominance (TFD) which is most varied in hormones and the hardest time being calm with mood swings along gaining equanimity also can be diagnosed congenital adrenal hyperplasia. [Retrieved Singleton, Omar, et al. “Change in Brain stem Gray Matter Concentration Following a Mindfulness-Based Intervention Is Correlated with Improvement in Psychological Well-Being.” Frontiers in Human Neuroscience, Frontiers Media S.A., 18 Feb. 2014].

Is there a worry gene? Yes… Silence this BDNF gene (common with OCD, Anxiety, Depression) doing the above activities. Researchers at Yale have identified a gene mutation for “rumination” — the kind of chronic worry in which people obsess over negative thoughts. It’s a variation of a gene known as BDNF that’s active in the hippocampus, an area of the brain involved in thinking and memory. Retrieved from  https://www.wsj.com/articles/SB120035992325490045

Bianca Jones Marlin, PhD, a neuroscientist and assistant professor of psychology at Columbia University, found that mice that had given birth are more likely to pick up crying pups than virgin animals and that the oxytocin released during the birth and parenting process actually changes the hearing centers of the brain to motivate prosocial and survival behaviors. Most importantly, The social hormone oxytocin also plays a role in facilitating empathy.(Retrieved from https://www.apa.org/monitor/2021/11/feature-cultivating-empathy?fbclid=IwAR2pz_TBwefQbmTUxg3XPiNfoXe-F8480VMpDH1c6KgpDtk3L552fDoTsaM; Nature, Vol. 520, No. 7548, 2015).

Researchers propose a new framework for three seemingly unconnected forms of creativity.

Creativity is understood as the creation of novel, useful and surprising solutions.

The researchers argue that the associated cognitive processes, such as the ability to abstract, improvise, or think divergently, involve different brain areas that are interconnected. These areas include the cerebellum, hippocampus, prefrontal cortex, and basal ganglia.

Different areas are activated depending on the type of creativity. The similarities and differences between these types of creativity and their neuronal circuits are described by the model with the help of algorithms. [Retrieved from https://neurosciencenews.com/neurobiology-creativity-20723/]

Come to Him (Power)- Humbled by His Honor for: He might be the Lord of both the dead and the living. ‘ (Romans) 14:9 In Christ to “Let it go, [and know] this too shall pass” 2 Corinthians 4: 17-18…God, Abba please send The Teacher for Goodness and The Comforter to her now…thank you, God.

Humbled by His Honor for: ‘And hope does not put us to shame, because God’s love has been poured out into our hearts through the Holy Spirit, who has been given to us. ‘ (Romans 5:5) ‘Let every soul be subject unto the higher powers. For there is no power but of God: the powers that be are ordained of God. ‘ Romans 13:1

LEARN MORE HERE

AVOID SHAME– ASUNETOS (Strong’s #801 — Adjective — asunetos — as-oon’-ay-tos ) “without understanding or discernment” (a, negative, sunetos, “intelligent, understanding”), is translated without understanding” in Matthew 15:16 : Mark 7:18; Romans 1:31; 10:19 , RV, “void of understanding” (AV, “foolish”); in Romans 1:21 , RV, “senseless” (AV, “foolish”).

Read Of Discernment Here

‘Now to Him who is able to keep you from stumbling or falling into sin, and to present you unblemished [blameless without shame) and faultless (pure of heart)] in the presence of His glory with triumphant joy and unspeakable delight, to the only God our Savior, through Jesus Christ our Lord, be glory, majesty, dominion, and power, before all time and now and forever. Amen.’ Jude 1:24-25

Learn More Here

Delight (mind-RAS-Gut): Strength, Might, Simple (Affirmation (Blessing of Thanksgiving): -Abound-Heart/Spirit, Justifying Faith-justice)

RAS – “The  Door” Rectangular Activation System

The RAS being activated via the pons, and thymus leads someone to a  “Flexible Mind”. This flexible mind is due to the transference of     “cells” and activating the synapse of the neurons to increase     neuroplasticity. A “Ridged Mind” is a closed mind-remember, if you  don’t use an “open mind”, you lose adaptability (placidity-that is, also read  below abstract thinking).  -Tricia Cook

14 – 2.3 RAS Rectangular Activation System Note: includes Soma and Alta Major Chakras illustration

Vagus Nerve & RAS Vibrating Alta Major Chakra (*aka God Awareness Chakra)

The Reticular Activating System (RAS)- Ras/ HPA & ACC/Gut – to know, perceive, recognize, have, aware, cognizant, do laugh, reverence, ask, repent, reconciliation which is a network of neurons (hyper-, hypo-, or, varied) located in the brain stem that project anteriorly to the hypothalmus to mediate behavior such as sleep, memory, and learning; as well as, both posteriorly to the and directly to the cortex for activation of awake, desynchronized cortical EEG patterns. The reticular formation (part of pons-see below) is a set of interconnected nuclei that are  located throughout the brain stem. It is not anatomically well-defined,  because it includes neurons located in different parts of the brain. The  neurons of the reticular formation make up a complex set of networks in  the core of the brain stem that extend from the upper part of the  midbrain to the lower part of the medulla oblongata. The reticular  formation includes ascending pathways to the cortex in the ascending  reticular activating system and descending pathways to the spinal cord  via the reticulospinal tracts. [2]  It is holistically and spiritually known from being a center “where we can create our own reality” whether positive, negative, or neutral. Knowing: What we focus on in our mind (thymus), pons (dream center) then comes to fruition here in our RAS. The reticular activating system’s fundamental role is regulating arousal and sleep−wake transitions. The ascending projections of the reticular activating system  enhance the attentive state of the cortex and facilitate conscious  perception of sensory stimuli. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013218/; https://commons.wikimedia.org/wiki/File:Gray701.png; https://en.wikipedia.org/wiki/Reticular_formation].

Targeting these cells, as reported in the journal #Nature Neuroscience,  modulated memory retrieval and altered anxiety-like behaviors in mice.  Essentially, the #UNC scientists boosted the electrical activity between  cells in the hypothalamus and the hippocampus to create new neurons – an  important process called neurogenesis “Targeting  the hypothalamic neurons to enhance adult hippocampal  neurogenesis will not only benefit brain functions,” said senior author @Juan Song, PhD, associate professor of pharmacology, “but also holds the  potential to treat cognitive and affective deficits associated with  various brain disorders.”  [Retrieved from https://neurosciencenews.com/optogenetics-neurogenesis-20603/].

Note: the thalamus has been found to be less passive in cognitive functions may indeed be supported by a more general role in  shaping mental representations. Several features of thalamocortical  circuits are consistent with this suggested role, and we highlight how  divergent and convergent thalamocortical and corticothalamic pathways  may complement each other to support these functions. Furthermore, the  role of the thalamus for subcortical integration is highlighted as a key  mechanism for maintaining and updating representations. [Retrieved from https://www.jneurosci.org/content/39/1/3?fbclid=IwAR1mUDSUOD3kolCFIoVRTXf6rsLZ6nbZfnMI8oRUEgwZ37EI8ppd3USLD2s]. Columbia University research, studied cognitive abnormalities associated with schizophrenia may be traced to altered activity in the thalamus during adolescence. The researchers have reported new evidence that  cognitive abnormalities seen in neuropsychiatric disorders such as  schizophrenia may be traceable to altered activity in the thalamus  during adolescence, a time window of heightened vulnerability for  schizophrenia. [Retrieved from https://neurosciencenews.com/thalamus-activity-schizophrenia-20641/].

The ACC (see top)- is part of RAS (Pineal Gland, Pituitary Gland) associated with the alta major chakra and shame.

HPA (see top)-(Hypothalamic–Pituitary–Adrenal Axis) associated with the soma chakra and anger.

Both are associated with the thymus chakra aka vagus nerve chakra.

Note: Important RAS info. includes the following excerpt… ‘The RAS is said to be the gas pedal [slow (hypo-), accelerate (hyper-) or varied cognitive speed processing] that ignites the diencephalon (the hypothalamus and thalamus) as well as the cortical areas [where all long-term memory/storage takes place] of the brain’ (Petty 1996). https://nlpca.com/creating-an-optimal-future-for-yourself/

Daniel Kahneman is correct, engaging the reader in a lively conversation about how we think, reveals where we can and cannot trust our intuitions and how we  can tap into the benefits of slow thinking [hypo-; as well hyper-, varied speed processing]. [Retrieved from https://suebehaviouraldesign.com/about-us/contact/See]

 Images Below: Left- hyper speed processing, Right- hypo- speed processing (then vice versa)

15 – Left- hyper speed processing, Right- hypo- speed processing

16 – Right- hyper speed processing, Left- hypo- speed processing

“Cognitive flexibility is related to our perceptions, emotions, actions and even our deep motivations. A change in environment, attitude, or  behavior will also influence the way we think. … When we are able to  make a mental shift without remaining stuck in a particular mindset,  we’re practicing mental flexibility.” [Retrieved from https://www.prospectmedical.com/resources/wellness-center/mental-flexibility].

“We all have what is needed for “elastic thinking”—to a greater extent,  perhaps, than we realize. It’s just a matter of recognizing the needed  skills, Mlodinow argues, and nurturing them. He answered questions from  Mind Matters editor Gareth Cook. “[Retrieved from https://www.scientificamerican.com/article/the-power-of-flexible-thinking/].

“Fix these words of mine in your hearts and minds; tie them as symbols on your hands and bind them on your foreheads.” Deuteronomy 6:8

The GUT- The SECOND Brain & Solar Plexus

The gut consist of 75% of our immune system, and the microbiome refers to the collective  genomes of the micro-organisms in a particular environment, and  microbiota is the community of micro-organisms themselves (box 1).  Approximately 100 trillion micro-organisms (most of them bacteria, but  also viruses, fungi, and protozoa) exist in the human gastrointestinal  tract12—the  microbiome is now best thought of as a virtual organ of the body. The  human genome consists of about 23 000 genes, whereas the microbiome  encodes over three million genes producing thousands of metabolites,  which replace many of the functions of the host,13 consequently influencing the host’s fitness, phenotype, and health.2

The human body is composed of a complex biological system; with over 90% of microbiota cells and 10 million microbiota genes (1),   it possesses over 100 trillion bacteria, 10 times the number of human   body cells, 150 times the number of human genes, 1,000 species and over   7,000 strains (2).  [Retrieved from https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00223/full].

• Microbiome—the collective genomes of the microorganisms in a particular environment
• Microbiota—the community of microorganisms themselves
• Microbiota diversity—a  measure of how many species and, dependent on the diverse indices, how evenly distributed they are in the community. Lower  diversity is considered a marker of dysbiosis (microbial imbalance) in  the gut and has been found in autoimmune diseases and obesity and  cardio metabolic conditions, as well a in elderly people.
• Colonocytes—epithelial cells of the colon

According to several studies, there is considerable evidence showing that the gut microbiome not only  affects the digestive, metabolic, and immune functions of the host but  also regulates host sleep and mental states through the  microbiome-gut-brain axis. Preliminary evidence indicates that  microorganisms and circadian genes can interact with each other. The  characteristics of the gastrointestinal microbiome and metabolism are  related to the host’s sleep and circadian rhythm. Moreover, emotion and  physiological stress can also affect the composition of the gut  microorganisms. The gut microbiome and inflammation may be linked to  sleep loss, circadian misalignment, affective disorders, and metabolic  disease. [Retrieved from https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00669/full].

Stress also exerts a great influence on the functions of our immune  system: if the immune system is somehow compromised and cannot properly  cope with physicochemical stresses [such as  food/nutrition, noise, pollution, metabolic disorder, infection, and inflammation], or if the stress exceeds the regular  adaptability of the immune system, this leads to diseased states that  may develop into fatal conditions. [Retrieved from https://www.frontiersin.org/research-topics/5755/stress-and-immunity].

LEARN More: Ancient grains in their “whole grain” form provide fibre, vitamins and minerals, healthy fats (listed HERE); especially farro is particularly high in protein and fiber, which may help maintain a healthy body weight by curbing your appetite and keeping you full after meals. Farro is also high in antioxidants  like polyphenols, carotenoids, and phytosterols, which may lower your  risk of several chronic illnesses, such as heart disease and certain  cancer (31Trusted Source, 32Trusted Source). Research shows that people who eat more whole grains may have a lower  risk of heart disease, stroke, diabetes, and some cancers- plus PCH other natural way of “Promot[ing] Overall Digestive Health” along with “Help[ing] Defend Against Occasional Constipation, Diarrhea, Gas and Bloating.”

17 – Retrieved from https://riteboost.com/dashboard/

See cell health above [Retrieved from Inflammation and Repair in Inflammatory Bowel Disease: Clinical, Translational and Experimental Studies https://www.frontiersin.org/research-topics/27082;  https://www.bmj.com/content/361/bmj.k2179}

The enteric nervous system (ENS) is a large division of the peripheral nervous system (PNS)  that can control gastrointestinal behavior independently of central  nervous system (CNS) input. Mammalian neurons are located in either the  CNS (brain and spinal cord) or PNS (cells with SOMA outside the brainleft  and spinal cord). Retrieved from https://neurosciencenews-com.cdn.ampproject.org/c/s/neurosciencenews.com/ent-gut-second-brain-19393/amp/

NOTE: The Soma and Ras (see epigenetics and learning disabilities above) cells regulate bodily processes. Therefore, needing neutrality, balance, equality of the thymus for cells to function with  cytoskeleton integrity, cell  proliferation, cell differentiation, cell  adhesion, apoptosis, and cell  migration (Read About RAS, soma, alta major chakras (energy centers-wheels) and cerebral cortex above).

Bliss (heart-pons): Joy, Power, Complete  (Intent (Praise of Trust):-Arise-Mind/Soul, Indwelling Faith-Love)

Pons- “The Gate” parts of the brain- I describe as heart not mind for that would be the RAS/Gut, and the thymus is the “Leb” which is heart/mind

18 – image 4.1 Pons Illustration works with RAS (*aka God Awareness Chakra)

19 – [nucleus accumbens. Retrieved from https://neuroscientificallychallenged.com/posts/know-your-brain-nucleus accumbens?fbclid=IwAR0ZYZEI0EBz6_VtZ4deghU1BeclAbJcKO3xZkmUq9zbYifNUHI45P338FA]

The pons is part of the brainstem that in humans and other bipeds lies  inferior to the midbrain, superior to the medulla oblongata and anterior  to the cerebellum. [1]  The pons integrates both the medulla oblongata and the thalamus (NOTE:  the importance of conscious reappraisal of emotions (emotional  reappraisal) such as shame/empathy and anger/strength for the ARAS).  In the thalamus, students can have a slow (hypo-), accelerated (hyper-) or varied processing, and they have a problem with sensory integration disorders (corollary discharge) and emotional intensity or insensitivity with their neurodifference. The Pons, like the RAS, is responsible for arousal (hyper-, hypo- and varied). Plus, the pons connects areas of the brain that controls autonomic functions (parasympathetic (shame) /sympathetic (anger)): Acting or occurring involuntarily, without conscious control, in the somatic nervous system such as sleep and histamine inhibitors: The part of the peripheral nervous system that transmits signals from the central nervous system to skeletal muscles, and from receptors of external stimuli such as mediating sight, hearing, and touch and movement including speaking with conscious control (RAS-alta major chakra, crown chakra specifically via the thymus (Vagus Nerve Chakra) [Retrieved from https://en.wikipedia.org/wiki/Pons].

 Ventral Tegmental Area (VTA)

The pons controls our breath known as ‘life’. God gave us the ‘life’, so  we can be the breath of God, leading a pure and blameless life. The  pons just doesn’t serve to help the different lobes communicate, but also  is the veil of God. The pons area also contains the trapezoid body  (RAS) where you are able to vocalize sounds. This allows us to  sing, praise and speak, and share His word- Hallelujah and Gregorian Chants and Turning Hatred/Grief into Joy: Ut Queant Laxis HERE. Note: from the (2016) study…higher-frequency LFP oscillation (CFC) is enhanced in the human brain  during high attentional demand, and has been linked to cognitive tasks  not only in cortical brain regions, but also in deep limbic structures, such as the amygdala, hippocampus, and nucleus accumbens. SEE hippocampus and olfactory sense below (Retrieved from https://www.jneurosci.org/content/36/49;  (Szczepanski et al., 2014);/12448?fbclid=IwAR0gqnyZ9b_0_ViS_yIa0186bY8Wkax6eZ_joF2fxTGLZqe8ZR5yO_pIvuI.; Structure and Function of the Brain | Boundless Psychology, https://courses.lumenlearning.com).

An interesting study recently has found: Volume decreases in cortical areas, the amygdala, and basal  forebrain in Parkinson’s patients correlated with worsening symptoms of  the disease. A team of researchers from Forschungszentrum Jülich,  Heinrich-Heine-University Düsseldorf and Ernst-von-Bergmann Klinikum  Potsdam analyzed the changes of brain volumes in 37 Parkinson’s patients  and 27 controls at up to 15 time points over up to 8.8 years using  magnetic resonance imaging (MRI). Previous in vivo studies had either  measured brain volumes in Parkinson’s patients only at fewer time points  or over shorter periods. [Retrieved from https://neurosciencenews.com/parkinsons-brain-volume-20610/?].

“All Scripture is God-breathed and is useful for teaching, rebuking, correcting and training in righteousness,..” https://www.bible.com/en-GB/bible/111/2TI.3.16.NIV

People also ask: What is the pons in the limbic system? Role of the pons in the carotid sympathetic chemoreflex?          

Carotid Body- The carotid body is a chemoreceptor located in the adventitia of the bifurcation of  the common carotid artery. Chemoreceptor function: Carotid body  monitors the blood’s pH, pCO2, and pO2 and thereby modulates  cardiovascular and respiratory function primarily through sympathetic  tone. [Retrieved from https://medicine.uiowa.edu/iowaprotocols/carotid-body-and-carotid-sinus-general-information].

The carotid chemoreceptor (CC) controls your breathing during exercise, The mass discharges of the splanchnic sympathetic (SND) and phrenic  nerves (PND) were recorded in urethananesthetized rats with resected  vagal and aortic nerves. Carotid chemoreceptor (CC) stimulation with N2  inhalation (4-12 s) or cyanide (50-100 micrograms/kg iv) activated SND  in bursts synchronized with the postinspiratory phase (mean SND  increase: 105 +/- 8%), raised AP, and increased PND rate and amplitude  (n = 40). Brain transection at superior collicular level produced no  effect. The sympathetic (SChR) and respiratory chemoreflexes (RChR) were  reduced after transections through the pons. Lesions of the  dorsolateral pons (dl-pons) produced CO2-dependent apneusis and/or  tachypnea at rest. [Retrieved from https://pubmed.ncbi.nlm.nih.gov/8067462/].

NDPs- “The cerebellar theory” (Nicolson, Fawcett, & Dean, 2001)  states, with mixed empirical support, that poor automaticity and motor  deficits in individuals with dyslexia may be associated with a  dysfunction of the cerebellum (Feng et al., 2017; Vias & Dick, 2017). [Retrieved from https://onlinelibrary.wiley.com/doi/10.1002/dys.1681?fbclid=IwAR3pdYZTYwoFMSFASW8CDJwzOpyNRVpMyt38K0_K-4IweECeBJZIrNbmaSE].

The  archipallium or primitive (“reptilian”) brain, comprising the  structures of the brain stem – medulla, pons, cerebellum, mesencephalon,  the oldest basal nuclei – the globus pallidus and the olfactory bulbs.  The paleopallium or intermediate (“old mammalian”) brain, comprising the  structures of the limbic system. Note: This is study on  and exercise-induced changes in the DA-D2R in the dopamine-depleted basal  ganglia are consistent with the potential role of this receptor in  modulating medium spiny neurons (MSNs) function and behavioral recovery.  The primary conclusion of our study is that exercise in the form of  intensive treadmill running facilitates neuroplasticity through  increased expression of striatal DA-D2Rs, a process most evident in the  injured brain. [Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273304/] . Note: In my program, I emphasize yoga, tai chi,qigong type exercises when in the stage of recognition of soul and intents- which works on the cellular level! [Retrieved from Google Image Result for Https://Biologydictionary.net/Wp-Content/Uploads/2020/11/Pons.jpg</i>, images.app.goo.gl/THSvxHLckja1]

The level of dopamine in the brain may have an impact on  emotional recognition in those with Parkinson’s disease and  schizophrenia, a new study reports. Emotion  recognition among people with disorders such as Parkinson’s disease or  schizophrenia may be affected by changes in the levels of dopamine in  the brain, say researchers at the University of Birmingham. Dopamine  is a chemical messenger – often known as the ‘happy hormone’ – that  carries signals controlling mental and emotional responses in the brain. Parkinson’s  disease and other neurological disorders are known for their links with  low or disrupted dopamine levels that cause those affected to struggle  with a number of social skills. This is the first time, however, that a  positive connection has been made between dopamine and the ability to  recognize emotions in others. [Retrieved from https://neurosciencenews.com/dopamine-emotion-20648/].

As well, researchers have designed a new method of  converting non-neural cells into functioning neurons that are able to  form synapses, dispense dopamine, and restore the function of neurons  undermined by Parkinson’s associated destruction of dopaminergic cells. [Retrieved from https://neurosciencenews.com/ipsc-dopamine-parkinsons-neurons-20568/]. As well,  exercise even improves motor behavior in people with Parkinson’s disease, but the exact mechanism is not known. One  possibility is through an increase in dopamine, a neurotransmitter  needed for motor and emotional control that declines as the disease  progresses. [Retrieved from https://neurosciencenews.com/exercise-dopamine-20592/].

Since the pons and the thymus (see below) as well as the RAS work together, Students with  (anger) Sympathetic Functional System Dominance (SFD) can have problems “Seeing God” (God’s Energy- lucid dreams, “bind on forehead”) and “feeling worthy” to be called on by God (Aphantasia)- for God awareness they need circumstantial evidence or can go to extreme become ulta-religious constantly “breaking down” the Bible and religion or non-religious completely. Those with a (shame) Parasympathetic Functional System Dominance (PFD) have difficulties with reliance and resilience that’s “Hearing God” (God’s Essence- symbols, voice, “tie on hands”) and “feeling enough” to be chosen by God- for God awareness being calm in the mind- being present and ruminating on past/future a must. (PONS is addressed more in My ELBERT program: includes PYAM & RAS exercises body, breath, calm delight through Prayer, Yoga, Affirmation, and Meditation which connects us to God- see section below). Note: Students with Sympathetic Functional System Dominance (SFD) and Parasympathetic Functional System Dominance (PFD) have high allergy rates and sleep disturbances (see other complications below) which contains the Glia, also called glial cells or neuroglial, are non-neuronal cells in the central nervous system (brain and spinal cord) and the peripheral nervous system.

20 – 4.1b Peripheral Nervous System illustration

(peripheral sends info. to CNS- has effect on CNS as well as EM Field  aka “the senses”)

21 – Image 4.1a Pons Axial illustration

Note: For those with Dysphonetic (auditory) and Dsyeidetic (visual-surface) Dyslexia, the medial longitudinal fasciculus of the pons carries information about the direction that the eyes should move. It connects the cranial nerve nuclei III (Oculomotor nerve), IV (Trochlear nerve) and VI (Abducens nerve) together, and integrates movements directed by the gaze centers (frontal eye field) and information about head movement (from cranial VIII, Vestibulocochlear nerve- which The vestibulocochlear nerve is unusual in that it primarily consists of bipolar neurons. It is the nerve responsible for the special senses of hearing (via the cochlear nerve), and balance (via the vestibular nerve). Then, the cochlea detects the magnitude and frequency of sound waves. Students with dyslexia have tendency for speech deficits and chronic ear infections, auditory as well as visual processing issues in the terms of being a sound and word processing disorder. Note: In some cases, it’s sometimes coordination, balance, and conflicting signals in the inner ear, eyes, and sensory receptors.

22 – Retrieved from https://epomedicine.com/medical-students/brodmann-areas-lesions/

Linguists are interested in language for its own sake, as a complex  product of the human mind. They are also interested in how language  develops in children, how it changes over time, and how it is used in  human society. Furthermore, Neuroscientist Suzana Herculano-Houzel has pointed out that our brains are different because of the number of neurons packed into our skulls — it’s less about the size of our brains. The density of that packing, and the ensuing neuronal connections this density allows for, gives rise to our ability to acquire language from birth and use it till death. She assumes that the main function of the brain is   to regulate our bodies as we move through life. That means that at   every given moment, our brains assess our hunger, threat levels, etc. to   figure out how much energy we need to get through the day. Thinking  and  cognitive perception are secondary products of how our brain  responds  predicatively to our environment. If the grammatical system is a resource that the brain uses depending on  context, then our emotions and identity can also affect how we use  grammar. This is precisely what we have found. [Retrieved from https://www.umass.edu/linguistics/; https://neurosciencenews-com.cdn.ampproject.org/c/s/neurosciencenews.com/emotion-grammar-linguistics-19790/amp/?fbclid=IwAR3Uu9_tlLeZS-7upnvBRvIbBvarR46E9SathZ7y3fKeLSoWBwQ8y4JZFnU].

In addition, these Brodmanns [see Ras and Pons above] have been widely redefined, discussed,  debated, and refined exhaustively based on cytoarchitecture, cortical  functions, and brain plasticity. Brodmann areas of the cerebral cortex are based on the types of neurons  and connections that typically found each region. For Dyslexia this includes the left hemisphere language zones of their brain, (ie  anatomic regions called Superior Temporal Gyrus, Angular Gyrus and  Supramarginal gyrus, Broca’s region). There are 52  Brodmann  regions, covering the primary somatosensory cortex, primary motor  cortex, somatosensory association cortex, premotor and supplementary  motor cortex, dorsolateral/anterior prefrontal cortex, anterior  prefrontal cortex, and primary visual and audio cortexes, plus  additional areas. BA18 of Brodmann (human) refers to a subdivision of the cytoarchitecturally defined occipital region of cerebral cortex. In the human it is located in parts of the cuneus, the lingual gyrus and the middle occipital gyrus of the occipital lobe. Brodmann area 22 is cytoarchitecturally located in the posterior superior temporal gyrus of the brain. In the left cerebral hemisphere, it is one portion of Wernicke’s area. The prefrontal cortex contains Brodmann areas  is thought to be involved in psychological functions such as executive  tasks, attention, and memory. This Research Topic, since they are the most rostral, and might be  involved in more elementary computations as compared to, say, BA46,  which is clearly involved in working memory. Also, Brodmann area 10 (BA10, frontopolar prefrontal cortex, rostrolateral prefrontal cortex, or anterior prefrontal cortex, the  area is “described as “one of the least well-understood regions of the human brain”.[2] Ronel (2018) conducted a similar analysis for ADHD, in terms of 4 types  of selection/inhibition (lateral BA 8 – motor selection/inhibition;  lateral BA 9 – emotion selection/inhibition; lateral BA 10 – memory  selection/inhibition; lateral BA 11 – sensory selection/inhibition). Present research suggests that it is involved in strategic processes in memory recall and various executive functions. During  human evolution, the functions in this area resulted in its expansion relative to the rest of the brain.[3]” [Retrieved from https://www.kenhub.com/en/library/anatomy/brodmann-areas;  https://www.frontiersin.org/articles/10.3389/fnbeh.2013.00198/full]

“Just as we live our life out of memory, thinking and dwelling in the  past as  a way of creating the future in the present by using the same  idea to  create a new variation, our body is regenerated and sustained  out of  the same memory. The mind forms an astral image as a hologram  that  imprints the etheric body with the information of that image.” [Retrieved from HERE; https://www.frontiersin.org/research-topics/19625/the-four-streams-of-the-prefrontal-cortex; http://ecotopia.org/thymos-as-biopsychological-metaphor-the-vital-root-of-consciousness/].

Happiness (heart mind- Thymus, heart/mind “the Leb”): Peace, Authority, Absolute (Revelation (Hope of Forgiveness): -Behold-Heart/Soul Saving Faith-peace)

Thymus- “The Second Gate”

23 – image 4.2 thymus illustration works with RAS illustration

(has an effect to peripheral, Vagus Nerve, CNS-  as well as EM Field  aka “the senses”)

 ‘T  cells are critical to the adaptive immune system’: Stopping Inflamation and Even Damage

The collaboration between Professor Adrian Liston (Babraham Institute)  and Professor Matthew Holt (VIB and KU Leuven; i3S-University of Porto)  has produced a targeted delivery system for boosting the numbers of  specialized anti-inflammatory immune cells specifically within the brain  to restrict brain inflammation and damage. The research team found that regulatory T cell numbers were low in  the brain because of a limited supply of the crucial survival molecule  interleukin 2, also known as IL2. Levels of IL2 are low in the brain  compared to the rest of the body as it can’t pass the blood-brain  barrier. Together the team devised a new therapeutic approach that  allows more IL2 to be made by brain cells, thereby creating the  conditions needed by regulatory T cells to survive. A ‘gene delivery’  system based on an engineered adeno-associated viral vector (AAV) was  used: this system can actually cross an intact blood brain barrier and  deliver the DNA needed for the brain to produce more IL2 production. [Retrieved from https://neurosciencenews.com/tbi-immune-system-20671/].

Thymus (12th chakra and all chakras, high heart & mind, inward man)-Upper or Higher Heart Chakra (*aka God Unity Chakra, Ascension Chakra, Vagus Nerve Chakra). It is the “one” umpire known as the mind. Thymus- to be, have, belong, remain, imagine living in love (wisdom, curiosity, “intellect”, connect)-It is known as “the seat of the soul”, and our Higher Intelligence & Imagination or “The Mind”- for the fact that it: holds a record of traumatic or painful events, dimensional to the subliminal content (see intelligence model below) and ancestral narration (see imagination).   High Heart Chakra, also called the ascended heart chakra, is connected with an organ: the thymus gland which before birth and throughout childhood (largest in the teen years-dormant at 50 years old). The thymus is a specialized primary  lymphoid organ of the immune  system. Within the thymus, thymus cell lymphocytes or T cells mature. T  cells are critical to the adaptive immune system (also see RAS-GUT), where the body adapts  specifically to foreign invaders. The thymus is located in the  upper  front part of the chest, in the anterior superior mediastinum, behind  the sternum, and in front of the heart. It is made up of two lobes, each  consisting of a central medulla and an outer cortex, surrounded by a  capsule. [2] The thymus is instrumental in the production and maturation of T-lymphocytes or T cells, a specific type of white blood cell that protects the body from certain threats, including viruses and infections; It plays a role in immunity, autoimmunity, and aging (it’s basically our twin flame and fountain of youth). It’s made up of a scheme showing development of branchial epithelial bodies from the  thoracic cavity of the foetus. I, II, III, IV. Branchial pouches. [4] The  human leukocyte antigen (HLA) system or complex is a complex of genes  on chromosome 6 in humans which encode cell-surface proteins responsible  for the regulation of the immune system.[1] The HLA system is also known as the human version of the major histocompatibility complex (MHC)  found in many animals.[2] More importanmtly, the “soul that is the seat of the mind”.  [Retrieved from https://www.hindawi.com/journals/jtrans/2012/842141/; https://www.unseenwarfare.net/3-powers-of-the-soul; https://www.science.org/doi/10.1126/scisignal.abc8579; https://en.wikipedia.org/wiki/Thymus].

The Monad and the Permanent Seed Atom  are different parts of the same functioning spirit body. When the seed  atom is coming online the Monadic light generates into the diamond  blueprint Diamond Heart filter of the permanent seed atom. The inner Monadic spirit ignites with the Mother’s Holy Spirit or the Amoraea Flame. The activated ‘Christ’ Seed Atom generates the instruction set of the Silicate Matrix and is the Universal Christos Field or 12D Ray. [Retrieved from https://ascensionglossary.com/index.php/Monad].

The Thymus and High Heart & Gut Relation

See Kidneys, See THYMUS (high heart), See Blood PH LEVELS: adrenal glands, also known as suprarenal glands, are small, triangular-shaped glands located on top of both kidneys here : The Spirit body of the Monad is only consciously aware of the contents of the Soul  when it is connected to the Soul. This is the same as when the physical  body is disconnected from the Soul, the conscious mind does not  remember her (cannot feel the soul). When our Heart is healed, there is a fire that is ignited inside the  Heart that is accessed, and the fire in the Heart is also in the  Kidneys. There is a triangle that connects the Heart into the Kidneys.  The Kidneys are in the base of the triangle from left to right and the  point of the triangle is in the Heart. When the Heart is healed, there  is a twin flame ignition in our Heart and Kidneys, which shifts the  Heart configuration. Twin flames equals structure of light within the  Heart. So two flames ignite in the Heart. The Monad  is the greater flame and the physical body is the lesser flame. When  this dual flame is ignited, there is an ignition in the Heart and a fire  coming into the Kidneys, which is about blood cleansing. [Retrieved from https://ascensionglossary.com/index.php/Monad].

“And  he who searches our hearts knows the mind of the Spirit, because the  Spirit intercedes for God’s people in accordance with the will of God.” Romans 8:27 Retrieved from https://www.bible.com/en-GB/bible/111/ROM.8.27.NIV

24 – Retrieved from http://www.mcblab.net/lecture/20132-/chapter-15.pdf

Thymus Ancient Extracellular Signaling Molecule Matrix (ECM)

The thymus includes ancient  extracellular signalling  molecules which are cues, such as growth factors, hormones, cytokines,  extracellular matrix components and neurotransmitters, designed to transmit specific information to target cells. Increasing knowledge about the roles of extracellular matrix and its components in the nervous system development and disease is important  from the therapeutic viewpoint. Activation of signaling cascades  underlying reorganization of the extracellular matrix and stimulation of  neuronal plasticity is an achievable goal and a promising approach for  treatment of acute and chronic neurodegenerative disorders. Recent data  suggest that extracellular matrix proteases modifying cell recognition  molecules on the neuronal surface, modulate synaptogenesis and  plasticity during development and neurorepair. [Retrieved from https://www.frontiersin.org/research-topics/21996/extracellular-matrix-in-development-and-disorders-of-the-nervous-system; https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.15776].

A new study reveals how adipocytes, or fat cells, play a role in  cognitive decline and increased neurodegeneration risks. Using  genetically modified mouse models, researchers found oxidative stress  through exposure to a Western diet increased the production of  inflammatory cytokines confined to adipocytes and altered protein  markers of memory and cognition in the hippocampus. [Retrieved from https://neurosciencenews-com.cdn.ampproject.org/c/s/neurosciencenews.com/fat-cells-cognition-19521/amp/?fbclid=IwAR0EsMm7hYb1k-f63z0CfVd5cLiHRJ_RNavyXvI4U-0Jow03LuqA3EueXpQ].

As well, sympathetic [Anger] innervation of the thymus originates from the superior  cervical and stellate ganglion. These fibers travel in a plexus along  large blood vessels until they enter the thymic capsule. Parasympathetic  fibers  [Shame]  arise from the vagus, recurrent laryngeal, and phrenic nerves.  Several rodent studies have found that thymocytes respond to stimuli via  norepinephrine, dopamine, acetylcholine, neuropeptide Y, vasoactive  intestinal peptide, calcitonin gene-related peptide, and substance P.[2][6][2] [Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK539748/].

Research on the molecular and cellular basis of learning and memory has  focused on the mechanisms that underlie the induction and expression of  synaptic plasticity. There is increasing evidence that structural  changes at the synapse are associated with synaptic plasticity and that  extracellular matrix (ECM) components and cell adhesion molecules are  associated with these changes (Retrieved from HERE).

“May our Lord Jesus Christ himself and God our Father, who loved us and by his grace gave us eternal encouragement and good hope, encourage your hearts and strengthen you in every good deed and word.”  

2 Thessalonians 2:16-17 https://www2.bible.com/bible/111/2TH.2.16-17

The Thymus aka Leb, Lebab Cont.

The leb is “:The Veil”, of the five senses, also what enters the body, and absolutely essential for physical life and  health, so too a healthy spiritual heart (mind (intellect), emotion (imagination), will (“ego”-good/love & bad/fear)) is at the center of one’s inner being (soul)  is vital for a healthy  soul, serving as the “fountain” of all moral attitudes and actions. The invisible realm of the spirit is as real as the visible world. In  fact, the Scripture tells us that it is even more real (Hebrews 11:3).  And just as God gave us five natural senses to interact with the  physical world, He gave us five spiritual senses to connect with the  supernatural world. The Leb- high heart, mind and “the gut” which is the bodily organ by means of which the raw data of experience is shaped into thoughts, concepts, or judgments. https://www.preceptaustin.org/heart_leb?fbclid=IwAR3sxBfseZ2LTzssTfOghYI_kfM-mtglVqyEqG3W7xAPJIQt3uODG9GjNdk

The puritan, John Flavel said, it’s light of the understanding, recognitions of the memory, seat of principles and the fountain of actions. John MacArthur – The “heart” commonly refers to the mind as the center of thinking and reason (Pr 3:3; 6:21;7:3), but also includes the emotions (Pr 15:15, 30), the will (Pr 11:20; 14:14), and thus, the whole inner being (Pr 3:5). The leb aka heart and mind carries along several other organs of the body (cf. ear and eyes already in Pr 4:20, 21) mentioned frequently in wisdom instruction: mouth, lips, and eyes (parallel to “eyelids” or “orbs” in Pr 4:25), mouth, lips, and even the foot and hand. The heart is the depository of all wisdom and the source of whatever affects speech (Pr 4:24), sight (Pr 4:25), and conduct (Pr 4:26, 27). 

“Our mind [“leb”] receives information that it turns into emotional thoughts that  act as a blueprint for shaping our material body, both inwardly and  outwardly. We literally become what we think and imagine.” Retrieved from https://medcraveonline.com/MOJPB/dna-the-phantom-effect-quantum-hologram-and-the-etheric-body.html?fbclid=IwAR199BUqYjWCvNGq2GCgdzl3d0n_lVzu_6na4KVVcYVuBzk-JeiM-CgRyDQ

Our Euphraino, “the flexible mind”,  relies the veil on The Truth in The gospel lies in your belief in Jesus’ coming to earth…please read below and think about how our subjective, discriminative  knowledge and wisdom leads to understanding everything in terms of the following:

His Intention (Salvation- All Children of God):                     

• Awareness
• Knowledge                             

Our Own Revelation- “listening heart”

• Wisdom

His Affirmation (Unity- “The Chosen”, Sons of God)

• Understanding

 Learn More HERE

He makes them listen to correction and commands…https://www.bible.com/en-GB/bible/111/JOB.36.10.NIV. In the past God overlooked such ignorance, but now he commands all people…

Note: The thymus (thymus chakra) brings Intelligence (God’s Affirmation- “mental acuteness”) and  Imagination (God’s Intention- “perceived reality”) to balance to form our own Beliefs (Will)- it’s ultimately the convergence of knowledge and wisdom to gain a better understanding of everything!!! Read here how: https://wp.me/pbJRHH-15A

Peace  I leave with you; my peace I give you. I do not give to you as the  world gives. Do not let your hearts be troubled and do not be afraid. John  14:27 https://www.bible.com/en-GB/bible/111/JHN.14.27.NIV

ARAS (“The PERFECT” LEB- Lowly and Child-like) THE NARROW GATE PLUS BREATHING & BLOOD’S PH LEVELS

AGAIN, What is meekness? Being “Out of Darkness” and Overtaken, Upon The Presence Of His Light

ARAS (Super Conscious, Crown, Tippy TOP of Head, Child-Like BLISS to Live, Laugh, & Love=Perceiving Heaven ON Earth)

ARAS- (Woe To Meekness, No Longer Sloth or Spiritual Apathy) understand and fear [awe of Love”] of the Lord  [“…with behavior that is a credit to the summons to God’s service,  living as becomes you] with complete lowliness [in heart]: of mind (humility) and meekness  (unselfishness, gentleness, mildness), with patience, bearing with one  another and making allowances because you love one another. Ephesians  4:2 AMPC   Note: Meekness is an attribute of  human nature and behavior that has been defined as an amalgam [a mixture or blend “a curious amalgam of the traditional (OT) and the modern (NT)”]  of righteousness, inner humility, and patience. Meekness is essentially an  attitude or quality of heart whereby a person is willing to accept and  submit without resistance to the will and desire of someone else.  [Retrieved from https://www.regent.edu/journal/inner-resources-for-leaders/spiritual-meekness-a-virtue-for-christian-leaders/].   Take My yoke upon you and learn of Me, for I am gentle (meek) and  humble (lowly) in heart, and you will find rest (relief and ease and  refreshment and recreation and blessed quiet) for your souls. [Jer.  6:16.] Matthew 11:29 AMPC  Lowliness of heart and mind  are indispensable in our approach to our Heavenly Father and our hope of  receiving revelation and sanctification. “Let nothing be done  through strife or vainglory; but in lowliness of mind let each esteem other better than themselves” (Philippians 2:3).   AND [Jesus] said to His disciples, Temptations (snares, traps set to  entice to sin) are sure to come, but woe to him by or through whom they  come! Luke 17:1 AMPC  Rejoice and exult in hope; be steadfast and  patient in suffering and tribulation; be constant in prayer. Romans  12:12 AMPC

Live, Laugh, & Love=Perceiving Heaven ON Earth (His “WORKS”- The Creator and Finisher)

I SEE SELF-CONTROL,  PATIENCE, GENTLENESS, JOY< DIVINE LOVE

I HEAR KINDNESS, GOODNESS, PEACE <DIVINE HONOR

I KNOW THE LORD, IN HIS ALMIGHTY SPLENDOR

c. Divine Majesty- releases Sovereignty, The Advocate (1) to become The Perfect Three-One Harmony (The Light of Life)

(8, 9, 1) High Priesthood of Jesus & Now we are being in Divine Consecration- Prepared/Set Apart= being “yoked”/corded to His mutual affection with Holy Love [Divine Majesty]; Therefore,  perceives as He does aka “The Leb” which Carries Us by Faith In Hope [Divine Love], Right Hand of Grace with The Fruit of The Spirit [Divine Honor], including His Godly aspects and attributes such as MEEKNESS and Virtue of love, peace, justice, selfless, mild, gentle. It is described in the Super conscious as being “The Rock“, and Strength of The “Oak Tree”, Gleam, Live Simple Truth, Observation of The Promises You Won (Victory), Protection, Serenity, Illuminati, The Halo who is friend always, advisor, & anchor. (ex. peace-loving, loving-kindness), &  Appreciate Everything.

Breathing is a vital behavior that is particularly amenable to  experimental investigation. We review recent progress on three problems  of broad interest. (i) Where and how is respiratory rhythm  generated? The preBötzinger Complex is a critical site, whereas  pacemaker neurons may not be essential. The possibility that coupled  oscillators are involved is considered. (ii) What are the  mechanisms that underlie the plasticity necessary for adaptive changes  in breathing? Serotonin-dependent long-term facilitation following  intermittent hypoxia is an important example of such plasticity, and a  model that can account for this adaptive behavior is discussed. (iii) Where and how are the regulated variables CO2  and pH sensed? These sensors are essential if breathing is to be  appropriate for metabolism. Neurons with appropriate chemosensitivity  are spread throughout the brainstem; their individual properties and  collective role are just beginning to be understood. [Retrieved from https://www.annualreviews.org/doi/abs/10.1146/annurev.neuro.26.041002.131103].

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Prayer & BREATHING DAILY

FERVENT PRAYER (Fervent,  Fervently)  A — 1: ἐκτενής  (Strong’s #1618 — Adjective — ektenes — ek-ten-ace’ ) denotes “strained, stretched” (ek, “out,” teino, “to stretch”); hence, metaphorically, “fervent,” 1 Peter 4:8 . Some mss. have it in Acts 12:5 ,  for the adverb (see B). Cp. ekteneia (with en), “intently,  strenuously,” in Acts 26:7 , AV, “instantly,” RV, “earnestly.” Cp.

EARNEST.  B — 1: ἐκτενῶς  (Strong’s #1619 — Adverb — ektenos — ek-ten-oce’ ) “fervently”

(akin to A), is said of love, in 1 Peter 1:22; of prayer, in  some mss. Acts 12:5 (see under A); for the comparative degree in Luke  22:44 , see EARNESTLY.  C — 1: ζέω  (Strong’s #2204 — Verb — zeo — dzeh’-o ) “to be hot, to boil” (Eng. “zeal” is akin), is metaphorically used of “fervency” of spirit, Acts 18:25; Romans 12:11 .  Notes: (1) In Colossians 4:12 , the verb agonizomai, “to strive,” is  translated “laboring fervently,” AV (RV, “striving”). (2) In 2  Corinthians 7:7 , the noun zelos, “zeal” (akin to C.), is translated  “fervent mind,” AV (RV, “zeal”). (3) In James 5:17 , “he prayed  fervently” (AV, “earnestly”) translates the noun proseuche, followed by the corresponding verb, lit., “he prayed with prayer.” In James 5:16  deesis, “supplication,” is so translated in the RV, for the AV,  “effectual fervent prayer.” There is nothing in the original corresponding to the word “effectual.” The phrase, including the verb  energeomai, “to work in,” is, lit., “the inworking supplication,”  suggesting a supplication consistent with inward conformity to the mind  of God. (4) For “fervent heat” see HEAT , B. A  — 1: ἐνεργής  (Strong’s #1756 —

• Adjective — energes — en-er-gace’ ) denotes “active, powerful in action” (en, “in,” ergon,
• “work;” Eng.  “energy;” the word “work” is derived from the same root). It is  translated
• “effectual” in 1 Corinthians 16:9 , of the door opened for  the Gospel in Ephesus, and made
• “effectual” in the results of entering  it; and in Philemon 1:6 , of the fellowship of Philemon’s faith “in the  knowledge of every good thing” (RV). In Hebrews 4:12 it describes the  Word of God as “active,” RV (AV, “powerful”), i.e., full of power to  achieve results. See ACTIVE , POWERFUL.

EFFECTUAL PRAYER B — 1: ἐνεργέω  (Strong’s #1754 — Verb — energeo — en-erg-eh’-o ) “to put forth power, be operative, to work” (its usual meaning), is  rendered by the verb “to work effectually,” or “to be effectual,” in the  AV of 2 Corinthians 1:6; Galatians 2:8; 1 Thessalonians 2:13; in each  case the RV translates it by the simple verb “to work” (past tense,  “wrought”). In James 5:16 the RV omits the superfluous word “effectual,”  and translates the sentence “the supplication of a righteous man  availeth much in its working,” the verb being in the present participial  form. Here the meaning may be “in its inworking,” i.e., in the effect  produced in the praying man, bringing him into line with the will of  God, as in the case of Elijah. For a fuller treatment of the word, see  WORK. See also DO , MIGHTY , SHEW , Note (11).

Note: The noun energeia, “working,” is translated “effectual working,”  in the AV of Ephesians 3:7; 4:16 See gnēsiōs- gnay-SEE-ose [Pure Heart] “sincerely, honorably” (akin to A, No. 3), is rendered “truly” (marg., “genuinely”) in Phil, 2:20 (AV, “naturally”).  Read More HERE* see image below The Trinity- US< GOD, UNIVERSE<LOVE= THREE IN ONE Show (sight) & Tells You (hear) IN WORD ABOUT The Future So Pray; Prayer and contemplation

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Who are considered the Neurodiverse?

What is neurodiversity? Individual differences in brain functioning regarded as normal variations within the human population because of genes, environmental, and intersecting factors. Intersecting identities is the concept that an individual’s identity  consists of multiple, intersecting factors, including but not limited  to gender identity, gender expression, race, ethnicity, class (past and  present), religious beliefs, sexual identity and sexual expression. [Retrieved from https://en.wikipedia.org/wiki/Intersectionality].

Developmental

Developmental Coordination Disorder (DCD)

Dyspraxia

Developmental Language Disorder (DLD)

Dyscalculia

Benign Rolandic Epilepsy (BRE)

Dyslexia

Autism Spectrum Condition (ASC)

Fetal Alcohol Syndrome (FASD)

Attention Hyperactivity Disorder (ADHD)

Visual Impairment (VI)

Chronic Fatigue Syndrome (CFS)

Physical/Mental

Hearing/Vision Impairment (HI)

Tic Disorders

Joint Hypermobility Syndrome (JHS)

Depression

Post Traumatic Stress Disorder (PSTD)

Anxiety Disorder

Borderline Personality Disorder (BPD)

Bipolar Disorder (BD)

Obsessive Compulsive Disorder (OCD)

Schizophrenia

Acquired

Migraines

Epilepsy

Traumatic Brain Injury (TBI)

Parkinsons

Huntingdons Chorea

Dementia

Motor Neuron Disease (MND)

Cerebral Vascular Accident (CVA)

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• Childhood trauma
• Dissemination Evidence-based treatment
• Learning collaborative
• Calm & Listening Skills
• Trainings on Neurodevelopmental Disorders (NDDs): Neurodiverity in Auditory Processing; Neurodevelopmental Disorders (NDDs): Neurodiverity in Visual Processing; Dysphonetic “Auditory” Dyslexia; Dyseidetic “Visual-Surface” Dyslexia; Directional “Geographic-Spacial” Dyslexia; Dysphoneidetic “Mixed” Dyslexia; Developmental Dyslexia; Acquired Dyslexia Stealth Dyslexia; Gifted & Talented; (2E) Twice Exceptionality; (ADHD-Any of the 3 types) Attention-Deficit Disorder;  (SPD) Sensory Processing Disorder; (IDD) Interoceptive Discrimination Disorder (DCD) Developmental Coordination Disorder; (SLI) Specific Language Impairment (DLD); Developmental Language Disorder *sounds and language; Irlen Syndrome; (APD) Auditory Processing Disorder such as Central Processing Disorder C(APD); (ASD/ASC) Autism Spectrum Disorder (VPD); Visual Processing Disorder such as Convergence Insufficiency (CI); (LD) Learning Disability General Processing Disorder (see terms above) such as  Hearing Loss/Impaired= those who use the term “hard of hearing“ (ID) Intellectual Disability (GDD) Global Developmental Delay; (TBI) Traumatic Brain Injury; Personality Disorder such as Narcism Behavioral Disorder such as ODD Obedient Defiant Disorder; Executive Functioning Problems or Disorder; OCD, Anxiety, & Depression; Schizophrenia (SZ) Epileptic Encephalopathies (EE) 

Evidence-based mental health interventions for traumatized youth: A st… https://www.sciencedirect.com/science/article/pii/S0005796711001367 

THE AUDITORY BRAINSTEM RESPONSE (ABR) & MEASURES OF PH IN THE BLOOD: EVALUATES RISK FACTORS FOR HEARING LOSS. This (1980) found fourteen of 100 unselected patients in an Intensive care nursery were  found by the auditory brainstem evoked response (ABR) method to suffer  significant hearing loss; of these 8 were ultimately discharged home.  Analysis of the 100 clinical records identified 9 risk factors of which  most, like low Apgar scores, are already known (Table I). However,  neonatal asphyxia appeared to be associated with hearing loss only when  repeated episodes of acidosis accompanied it (Table III). We conclude  that the ABR readily identifies the hard-of-hearing premature and  estimates the type and amount of his peripheral hearing loss, and that  physiological events associated with prolonged perfusion of the cochlea  with blood low in pH may be the most common cause of hearing disorder in  this group. [Retrieved from https://www.nature.com/articles/pr198036].

What makes a PH level to be considered healthy? Think about other diversities? See THYMUS (high heart)-ARAS (thymus, pons, RAS/HPA & ACC): adrenal glands, also known as suprarenal glands, are small, triangular-shaped glands located on top of both kidneys.

A normal blood pH level is 7.35 to 7.45 on a scale of 0 to 14,  where 0 is the most acidic and 14 is the most basic. This value can  vary slightly in either direction. If the lungs or kidneys are  malfunctioning, your blood’s pH level can become imbalanced. Intracellular pH (pHi) regulation in the brain is important in both physiological and physiopathological conditions because changes in pHi generally result in altered neuronal excitability. In this review, we will cover 4 major areas: (1) The effect of pHi on cellular processes in the brain, including channel activity and neuronal excitability. (2) pHi homeostasis and how it is determined by the balance between rates of acid loading (JL) and extrusion (JE). The balance between JE and JL determine steady-state pHi, as well as the ability of the cell to defend pHi  in the face of extracellular acid-base disturbances (e.g., metabolic  acidosis). (3) The properties and importance of members of the SLC4 and  SLC9 families of acid-base transporters expressed in the brain that  contribute to JL (namely the Cl-HCO3 exchanger AE3) and JE (the Na-H exchangers NHE1, NHE3, and NHE5 as well as the Na+- coupled HCO3−  transporters NBCe1, NBCn1, NDCBE, and NBCn2). (4) The effect of  acid-base disturbances on neuronal function and the roles of acid-base  transporters in defending neuronal pHi under physiopathologic conditions. [Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923155/].

Retrieved from https://www.achieveability.org.uk/files/1460064713/neurodiversity-with-reference-to-dyspraxia-mary-colly.pdf; American Psychiatric Association (1994) DSM-IV-TR Diagnostic and Statistical Manual of Mental Disorders. Washington DC, APA, https://www.psychiatry.org/patients-families.

Note: With Neurodevelopmental Disorders (NDDs), comes neurodivergency, you use inductive reasoning to solve problems, which is a  cause-and-effect type of thinking,  where someone begins identifying patterns by empirical observations of feelings and the future applications  Neuodivergency means having an induction logic versus deduction like a vast  majority of people. With this being said, disparagement can happen and cause trauma. Disparagement can be soul crushing!

Specific Leaning Disability (SLD) “An estimated 80 percent of those with learning disorders have reading  disorder in particular (commonly referred to as dyslexia). One-third of  people with learning disabilities are estimated to also have  attention-deficit hyperactivity disorder (ADHD).”

Retrieved from https://www.psychiatry.org/patients-families/specific-learning-disorder.

Autism Spectrum Condition (ASC) ” Exogenous prenatal risks are evident (e.g. valproate and toxic  chemicals) or possible (e.g. selective serotonin reuptake inhibitors),  and processes endogenous to the materno-foeto-placental unit (e.g.  maternal diabetes, enhanced steroidogenic activities and maternal immune  activation) likely heighten offspring vulnerability to ASC.” [Retrieved from https://acamh.onlinelibrary.wiley.com/doi/abs/10.1111/jcpp.12501].

Other

Seasonal Affective Disorder (SAD) include fatigue, even with too much sleep, and weight gain  associated with overeating and carbohydrate cravings. SAD may begin at any age, but it typically starts when a person is between ages 18 and 30. SAD symptoms can  vary from mild to severe and can include many symptoms similar to major. [See here-

Retrieved from https://www.psychiatry.org/patients-families/depression/seasonal-affective-disorder].

PTSD- Many advances in science have been made in the last decade to better  explain the pathogenesis of PTSD. Advances in the brain imaging method  have allowed us to study changes in patients’ brains in a non-invasive  way. Recent studies have observed the activity or morphology changes of  several brain regions in patients with PTSD, including the prefrontal  lobe, amygdala, hippocampus. However, it is still unclear how these  changes in brain regions are linked to PTSD. Further research needs to  be conducted to understand the function of brain regions during the  development of PTSD. Also, people can develop PTSD, depression, or both  as a result of a major traumatic event. The  hypothalamic–pituitary–adrenal axis (HPA axis) may play an important  role in such a difference (see HPA and anger above). [Retrieved from https://www.frontiersin.org/research-topics/21025/comprehensive-understanding-of-ptsd-from-pathogenesis-to-intervention].

Pathological Demand Avoidance of PDA is becoming more widely recognized as a distinct profile of autism. British psychologist Elizabeth Newson  came up with this term which describes an anxiety-driven need to be in  control and avoid other people’s demands and expectations. Demand avoidance in the PDA profile looks different from what others on  the autism spectrum experience because of its extreme nature and  obsessive quality. Research  done at the University of Newcastle in November 2016 found that  Intolerance of Uncertainty (IU) was also associated with PDA, in fact  even stronger than anxiety. [Retrieved from https://autismawarenesscentre.com/an-introduction-to-pathological-demand-avoidance-pda/?fbclid=IwAR3wuIGRCU3nViiYIxbqAHj0zKhPvWERF7y536oUXy5lIXan17ZOD1soaYc].

For many people, a traumatic experience can leave an indelible  impression on the brain in the form of post-traumatic stress disorder  (PTSD). PTSD is characterized by hyperarousal and avoidance of risky,  potentially aversive behaviors. [Retrieved from https://neurosciencenews.com/ptsd-valence-system-19569/].

Deficient emotional self-regulation (DESR) is a relatively new term used  to describe the problem of impulsive emotion coupled with emotional  self-regulation difficulties — issues long associated with attention  deficit hyperactivity disorder (ADHD or ADD). DESR may be new to the  ADHD lexicon, however I argue that it is a core and commonly overlooked  component of the disorder — and one that can help predict a patient’s  impairments, and even improve diagnostic and treatment practices.1

Dysthymia- People  with untreated ADHD can suffer from dysthymia  — a mild but long-term  mood disorder or sadness. It is often brought  on by living with the  frustrations, failures, negative feedback, and  stresses of life due to  untreated or inadequately treated ADHD. People  who are dysthymic suffer  almost every day from low energy and  self-esteem. [Retrieved from https://www.additudemag.com/slideshows/adhd-emotions-understanding-intense-feelings/‘].

Borderline Personality Disorder  (BPD)- What is also interesting is that ‘child maltreatment and efficiency of the conflict attention (Alerting, Orienting, and Executive Function Networks)  and their interactions of the networks along with their independently  predicted scores on the (BPD) precursors  composite. Maltreated children had higher mean  scores on the BPD  precursors composite, and children classified as having  high levels of  these precursors were more prevalent in the maltreatment  group.’ Development and Psychopathology Volume 17, Issue 4, December 2005, pp. 1071 – 1089  DOI: https://doi.org/10.1017/S0954579405050509.

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Humbled  by His Faith, for:  “You will need to position yourself for a  breakthrough. Quit pondering the past. In other words, stop dwelling on  your past failures and those things that just didn’t seem to go right  for you [personal/other expectations- guilt]. “Chronicles 20:17.

A study of human brain tissue suggests clinical depression reduces the quantity of astrocyte cells in key regions

Depression (major depressive disorder) is a common  and serious medical illness that negatively affects how you feel, the  way you think and how you act. Fortunately, it is also treatable.  Depression causes feelings of sadness and/or a loss of interest in  activities once enjoyed. It can lead to a variety of emotional and  physical problems and can decrease a person’s ability to function at  work and at home. [Retrieved from https://www.psychiatry.org/patients-families/depression]

In another study, they studied how loneliness is correlated with a higher risk of developing mental conditions. They studied how deterioration can occur in physical health, and is linked to  mortality and higher health care utilizationa combination of personality traits and childhood circumstances account for why some older people  experience loneliness more than others. Lonely adults over 50 were 1.24  times more likely to have rarely, or never, had comfortable friendships  during childhood, and 1.34 times more likely to have had poor  relationships with their mothers as children [think about impacts of learning with trauma…Retrieved from https://neurosciencenews.com/childhood-personality-loneliness-20606/].

In a present study, “The researchers were particularly interested in  three brain regions, the  dorsomedial prefrontal cortex (see Ras- HPA),  dorsal caudate nucleus and mediodorsal  thalamus  (see Ras- ACC), which  have been implicated in depression  (see Pons).” (*see mainly  HPA-anger/ACC-shame related to RAS in section above related to Pons and  Thymus) Retrieved from https://www.psypost.org/2021/05/new-study-of-human-brain-tissue-suggests-clinical-depression-reduces-the-quantity-of-astrocyte-cells-in-key-regions-60668 by Eric W. Dolan; May 4, 2021in Cognitive Science, Depression.

25 – dorsomedial prefrontal cortex controlled subconsciously by HPA (anger)

26 – dorsal caudate nucleus controlled subconsciously by ACC (shame)

27 – mediodorsal thalamus controlled subconsciously by PONS (anger/shame)

The gut microbiota forms part of a complex network termed the  microbiota-gut-brain axis along with the enteric nervous system,  sympathetic and parasympathetic divisions of the autonomic nervous  system, neuroendocrine and neuroimmune components the central nervous  system. The gut microbiota is associated with…The gut microbiota forms part of a complex network  termed the microbiota-gut-brain axis along with the enteric nervous  system, sympathetic and parasympathetic divisions of the autonomic  nervous system, neuroendocrine and neuroimmune components the central  nervous system. The gut microbiota is associated with neuropsychiatric  disorder such as schizophrenia, autistic disorders, anxiety disorders,  major depression and bipolar disorder. Major depressive disorder is a stress-related mood disorder associated  with a disrupted HPA axis, and evidence suggests that the gut microbiota  play a key role in modulating depression. Bipolar disorder is a severe  psychiatric disorder with dysfunctions of neuroimmune system which also  suggest the brain-gut-microbiota axis is an important physiological  mechanism. (See  Dysautonomia, HPA and anger above).

Communication from gut to brain occurs through tryptophan,  an essential building block of serotonin. Serotonin is key in  regulating mood, eating, and sleep patterns. There is limited storage  capacity for tryptophan in the brain, and a constant supply is required  from the gut. It was once believed that tryptophan came strictly from  diet alone, but what research has shown is that gut microbiota,  particularly Bifidobacterium, produces tryptophan and increases its levels in the bloodstream. This study below has since been replicated, adding to global evidence linking  the microbiome-gut-brain axis to stress and mental health disorders. Low  diversity in the gut microbiota is now considered a significant  biomarker for major depressive disorder. Other mental health and  neurodegenerative disorders with significant microbiome-gut-brain ties  include: post-traumatic stress disorder, bipolar disorder, schizophrenia, Parkinson’s disease, and autism. The microbiome-gut-brain axis also plays a critical role in irritable bowel syndrome, and in understanding the link between mental health disorders and physical illness, such as depression or anxiety co-occurring with inflammatory bowel disease. (Retrieved from https://trauma.blog.yorku.ca/2021/10/what-gut-bacteria-can-teach-us-about-mental-illness/?fbclid=IwAR0v5JnnKUkwHyd3vFTYulwq_tWc-jje5uO9jB7JShBQiNAwVdeidSw4rUM].

Lastly,  potential  mechanism include changes in microbial content, immune  stimulation, neural pathways (via the vagus nerve), tryptophan  metabolism, gut hormonal response, and bacterial metabolites.

Retrieved from https://www.frontiersin.org/research-topics/7323/involvement-of-neuro-immune-mechanism-and-brain-gut-axis-in-pathophysiology-of-mood-disorders

Other NDD’s

Most people are unaware of the connection between dyslexia and ADD or ADHD. It has been estimated that between 30 – 60% of kids with dyslexia also have either ADD or ADHD.

“Challenges with processing emotions start  in the brain itself. Sometimes the working memory impairments of ADHD  allow a momentary emotion to become too strong, flooding the brain with  one intense emotion.” Thomas Brown, Ph.D.

Brain imaging studies demonstrate that  chemicals that activate reward-recognizing circuits in the brain tend to  bind on significantly fewer receptor sites in people with ADHD than do  those in a comparison group. People with ADHD are less able  to anticipate pleasure or register satisfaction with tasks for which the  payoff is delayed.

Few doctors factor in emotional challenges  when making an ADHD diagnosis. In fact, current diagnostic criteria for  ADHD include no mention of “problems with emotions.” At other times,  working memory impairments leave the person with  insufficient sensitivity to the importance of a particular emotion  because he or she hasn’t kept other relevant information in mind. Challenges with emotions start in the brain itself. Sometimes the working memory impairments  of ADHD allow a momentary emotion to become too strong, flooding the  brain with one intense emotion [emotional intensity or insensitivity]. At other times, the person with  ADHD seems insensitive or unaware of the emotions of others.  Brain connectivity networks carrying information related to emotion seem  to be somewhat more limited in individuals with ADHD.

Gifted & Talented Plus 2e

The term “twice-exceptional,” also referred to as “2e,” is used to  describe gifted children who, have the characteristics of gifted  students with the potential for high achievement and give evidence of  one or more disabilities as defined by federal or state eligibility  criteria. These disabilities may include specific learning disabilities  (SpLD), speech and language disorders, emotional/behavioral disorders,  physical disabilities, autism spectrum, or other impairments such as  attention deficit hyperactivity disorder (ADHD) [Retrieved from https://www.nagc.org/resources-publications/resources-parents/twice-exceptional-students.

Emotional Intensity (see pons above and insensitive below)- It is characterized by heightened and intense feelings, a constant stream of both positive and negative feelings – pain, distress, despair, fear, excitement, love, sadness or happiness – sometimes a mixture of many at the same time; For my program, it’s mainly: anger, shame, happiness (joy), grief, courage (might), and harmony!

Emotionally overexcitable (OE) is often the first to be noticed by parents. It is reflected in heightened, intense feelings, extremes of complex emotions, identification with others’ feelings, and strong affective expression (Piechowski, 1991). Other manifestations include physical responses like stomachaches and blushing or concern with death and depression (Piechowski, 1979).  Emotionally overexcitable people have a remarkable capacity for deep relationships; they show strong emotional attachments to people, places, and things (Dabrowski & Piechowski, 1977). They have compassion, empathy, and sensitivity in relation-ships. Those with strong Emotional OE are acutely aware of their own feelings, of how they are growing and changing, and often carry on inner dialogs and practice self-judgment (Piechowski, 1979, 1991). Children high in Emotional OE‚ are often accused of “overreacting.” Their compassion and concern for others, their focus on relationships, and the intensity of their feelings may interfere with everyday tasks like homework or doing the dishes. [Retrieved from https://www.sengifted.org/post/overexcitability-and-the-gifted]. 

Also- Dabrowski identified five areas of intensity-Psychomotor, Sensual [MORAL], Intellectual, Imaginational, and Emotional- please think of hyper-, hypo- and varied thymus as it relates to being balanced, regulated, calm and homeostasis can happen!!

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